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The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine
Author(s) -
Ghaneifar Zahra,
Yousefi Zahra,
Tajik Fatemeh,
Nikfar Banafsheh,
Ghalibafan Fatemeh,
Abdollahi Elham,
MomtaziBorojeni Amir Abbas
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2399
Subject(s) - curcumin , pregnancy , oxidative stress , medicine , curcuma , preeclampsia , gestational diabetes , adverse effect , pathogenesis , intrauterine growth restriction , placenta , inflammation , antioxidant , fetus , bioinformatics , pharmacology , gestation , immunology , traditional medicine , biology , biochemistry , genetics
Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa , is mainly known by its anti‐inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcumin on dysregulated inflammatory and oxidative responses in various pregnancy complications.