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Nuclear‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 ( NR5A2 ) in the regulation of mitochondrial metabolism, cell survival, and cancer
Author(s) -
Michalek Svenja,
Brunner Thomas
Publication year - 2021
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2386
Subject(s) - crosstalk , liver receptor homolog 1 , nuclear receptor , microbiology and biotechnology , biology , mitochondrion , receptor , cancer research , transcription factor , genetics , gene , physics , optics
Abstract Liver receptor homolog‐1 (LRH‐1, NR5A2) is an orphan nuclear receptor with widespread activities in the regulation of development, stemness, metabolism, steroidogenesis, and proliferation. Many of the LRH‐1‐regulated processes target the mitochondria and associated activities. While under physiological conditions, a balanced LRH‐1 expression and regulation contribute to the maintenance of a physiological equilibrium, deregulation of LRH‐1 has been associated with inflammation and cancer. In this review, we discuss the role and mechanism(s) of how LRH‐1 regulates metabolic processes, cell survival, and cancer in a nuclear‐mitochondrial crosstalk, and evaluate its potential as a pharmacological target.