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Boosting the autophagy‐lysosomal pathway by phytochemicals: A potential therapeutic strategy against Alzheimer's disease
Author(s) -
Nourbakhsh Fahimeh,
Read Morgayn I.,
Barreto George E.,
Sahebkar Amirhossein
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2369
Subject(s) - autophagy , lysosome , microbiology and biotechnology , disease , signal transduction , organelle , biology , batten disease , inflammation , alzheimer's disease , tfeb , neuroscience , medicine , immunology , biochemistry , enzyme , pathology , apoptosis
The lysosome is a membrane‐enclosed organelle in eukaryotic cells, which has basic pattern recognition for nutrient‐dependent signal transduction. In Alzheimer's disease, the already declining autophagy‐lysosomal function is exacerbated by an increased need for clearance of damaged proteins and organelles in aged cells. Recent evidence suggests that numerous diseases are linked to impaired autophagy upstream of lysosomes. In this way, a comprehensive survey on the pathophysiology of the disease seems necessary. Hence, in the first section of this review, we will discuss the ultimate findings in lysosomal signaling functions and how they affect cellular metabolism and trafficking under neurodegenerative conditions, specifically Alzheimer's disease. In the second section, we focus on how natural products and their derivatives are involved in the regulation of inflammation and lysosomal dysfunction pathways, including how these should be considered a crucial target for Alzheimer's disease therapeutics.