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lncRNA ZEB2‐AS1 : A promising biomarker in human cancers
Author(s) -
Mahboobeh Zarei,
Pegah Mousavi,
Fatemeh Sadri,
Elham Karimi,
Hanieh Azari,
Milad Rafat,
Mohammad Shekari
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2338
Subject(s) - biology , carcinogenesis , long non coding rna , homeobox , cancer research , cancer , biomarker , antisense rna , zinc finger , function (biology) , gene , rna , microbiology and biotechnology , genetics , transcription factor
Abstract Long non‐coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non‐coding zinc finger E‐box binding homeobox 2 antisense RNA1 (lnZEB2‐AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2‐AS1 can lead to tumorigenesis and cancer progression. lncZEB2‐AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2‐AS1 in cells and its function in cancer progression.