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Mammalian polyamine metabolism and function
Author(s) -
Pegg Anthony E.
Publication year - 2009
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.230
Subject(s) - polyamine , metabolism , function (biology) , spermine , cellular metabolism , biochemistry , microbiology and biotechnology , biology , chemistry , enzyme
Abstract Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism. © 2009 IUBMB IUBMB Life 61(9): 880–894, 2009