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MiR ‐3613‐3p from carcinoma‐associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression
Author(s) -
Liu Yonglei,
Yang Yanfei,
Du Junxian,
Lin Dong,
Li Feng
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2292
Subject(s) - microvesicles , metastasis , cancer research , downregulation and upregulation , microrna , cell growth , biology , breast cancer , cell , cancer , biochemistry , genetics , gene
Exosomes carrying microRNAs (miRNAs) mediate cell‐to‐cell communication, which play important roles in cancer growth and progression. However, the roles and molecular mechanisms of the miRNAs in the exosomes from carcinoma‐associated fibroblasts (CAFs) are still not clear. The miRNA array showed that miR‐3613‐3p was an upregulated miRNA in CAFs exosomes. It was verified that miR‐3613‐3p was upregulated in exosomes from fibroblasts educated by TGF‐β1 and the fibroblasts from breast cancer tissues. Exosomal miR‐3613‐3p promoted breast cancer cell proliferation and metastasis. The cellular functions showed that miR‐3613‐3p downregulation in the CAFs exosomes suppressed cell proliferation and metastasis in breast cancer by targeting SOCS2 expression. The clinical data showed that miR‐3613‐3p levels were negatively related to SOCS2 expression in breast cancer tissues. In a conclusion, the study demonstrated that activated fibroblasts exosomes with high levels of miR‐3613‐3p played an oncogenic role in breast cancer cell survival and metastasis, which suggested that miR‐3613‐3p function as a therapeutic target.