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How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
Author(s) -
Yaghoubi Sajad,
Najminejad Hamid,
Dabaghian Mehran,
Karimi Mohammad Hossein,
AbdollahpourAlitappeh Meghdad,
Rad Fariba,
MahiBirjand Motahareh,
Mohammadi Shiva,
Mohseni Fatemeh,
Sobhani Lari Mohammad,
Teymouri Gholam Hossein,
Rigi Yousofabadi Esmat,
Salmani Abbas,
Bagheri Nader
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2275
Subject(s) - microvesicles , angiogenesis , tumor microenvironment , hypoxia (environmental) , microrna , secretion , microbiology and biotechnology , biology , cancer research , cell type , function (biology) , cell , chemistry , tumor cells , gene , endocrinology , biochemistry , organic chemistry , oxygen
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell‐derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.