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GATA factor transcriptional activity: Insights from genome‐wide binding profiles
Author(s) -
Romano Oriana,
Miccio Annarita
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2169
Subject(s) - epigenetics , biology , chromatin immunoprecipitation , transcription factor , zinc finger , genome , genetics , chromatin , computational biology , gene , transcriptional regulation , human genome , gene expression , promoter
The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome‐wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA‐factor‐induced transcriptional and epigenetic changes have now been analyzed at unprecedented levels of detail. Here, we review the results of genome‐wide studies of GATA factor occupancy in human and murine cell lines and primary cells (as determined by chromatin immunoprecipitation sequencing), and then discuss the molecular mechanisms underlying the mediation of transcriptional and epigenetic regulation by GATA factors.