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Overactivation of the sodium–calcium exchanger and transient receptor potential in anesthesia‐induced malignant hyperthermia
Author(s) -
Zhao Peng,
Liu Xiumin,
Sun Qianchuang,
Cui Yunfeng
Publication year - 2019
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2138
Subject(s) - malignant hyperthermia , calcium , hyperthermia , anesthesia , endoplasmic reticulum , medicine , sodium , chemistry , biochemistry , organic chemistry
Malignant hyperthermia is a pharmacogenetic disorder, which is an uncommon but frequently fatal intricacy of inhalation anesthesia in man. It causes a quick rise in body temperature to highly irreversible levels, which causes death in around three of four cases. The trigger anesthetics cause an anomalous, continued ascent in myoplasmic calcium levels. Possible mechanisms by which continuous release of sodium, calcium from skeletal muscle plasma membrane and sarcoplasmic reticulum stores respectively can produce the profound hyperthermia are discussed.