The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer | Zendy

Parizadeh Seyed Mostafa | Zendy; JafarzadehEsfehani Reza | Zendy; FazilatPanah Danial | Zendy; Hassanian Seyed Mahdi | Zendy; Shahidsales Soodabeh | Zendy; Khazaei Majid | Zendy; Parizadeh Seyed Mohammad Reza | Zendy; GhayourMobarhan Majid | Zendy; Ferns Gordon A. | Zendy; Avan Amir | Zendy

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The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer

Author(s) -

Parizadeh Seyed Mostafa,

JafarzadehEsfehani Reza,

FazilatPanah Danial,

Hassanian Seyed Mahdi,

Shahidsales Soodabeh,

Khazaei Majid,

Parizadeh Seyed Mohammad Reza,

GhayourMobarhan Majid,

Ferns Gordon A.,

Avan Amir

Publication year - 2019

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1002/iub.2063

Subject(s) - hepatocyte growth factor , cancer research , signal transduction , c met , colorectal cancer , receptor tyrosine kinase , metastasis , angiogenesis , epithelial–mesenchymal transition , cancer , carcinogenesis , medicine , tyrosine kinase , cell growth , biology , receptor , microbiology and biotechnology , genetics

Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer‐related mortality globally. In spite of the improvements in the early diagnosis of CRC, approximately one‐third of patients develop metastasis and then have a very poor survival rate. The mesenchymal–epithelial transition factor (c‐MET) is a tyrosine kinase cell surface receptor activated by hepatocyte growth factor (HGF). Activation of c‐MET/HGF signaling pathway regulates a variety of biological processes including cell motility, cell proliferation, angiogenesis, the epithelial‐to‐mesenchymal transition, and the development and progression of cancer cells. Recent studies have suggested that the c‐MET/HGF signaling pathway is involved in the carcinogenesis of CRC. In this review, we summarize the main findings of recent studies investigating the role of c‐MET/HGF signaling pathway in CRC and the potential of the c‐MET/HGF signaling pathways in the diagnosis and treatment of CRC. © 2019 IUBMB Life, 2019

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