Premium
Effects of curcumin on ion channels and pumps: A review
Author(s) -
Tabeshpour Jamshid,
Banaeeyeh Sara,
Eisvand Farhad,
Sathyapalan Thozhukat,
Hashemzaei Mahmoud,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2054
Subject(s) - curcumin , chemistry , curcuma , antioxidant , polyphenol , biochemistry , covalent bond , molecule , ion channel , combinatorial chemistry , traditional medicine , organic chemistry , medicine , receptor
Curcumin, an orange‐yellow lipophilic polyphenolic molecule, is the active component of Curcuma longa , which is extensively used as a spice in most of the Asian countries. This natural compound is able to interact with a large number of molecular structures like proteins, enzymes, lipids, DNA, RNA, transporter molecules, and ion channels. It has been reported to possess several biological effects such as antioxidant, anti‐inflammatory, wound healing, antimicrobial, anticancer, antiangiogenic, antimutagenic, and antiplatelet aggregation properties. These beneficial effects of curcumin are because of its extraordinary chemical interactions such as extensive hydrogen and covalent bonding, metal chelation, and so on. Therefore, the aim of this review was to outline the evidence in which curcumin could affect different types of ion channels and ion channel‐related diseases, and also to elucidate basic molecular mechanisms behind it. © 2019 IUBMB Life, 2019