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Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals
Author(s) -
Park Brenden C.,
Reese Michael,
Tagliabracci Vincent S.
Publication year - 2019
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2040
Subject(s) - kinase , intracellular , microbiology and biotechnology , biology , function (biology) , extracellular , bacteria , intracellular parasite , protein kinase a , biochemistry , genetics
Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites. © 2019 IUBMB Life, 71(6):749–759, 2019