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Giving off mixed signals—Distinct functions of α 5 β 1 and α v β 3 integrins in regulating cell behaviour
Author(s) -
Morgan Mark R.,
Byron Adam,
Humphries Martin J.,
Bass Mark D.
Publication year - 2009
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.200
Subject(s) - integrin , chemistry , materials science , cell , biochemistry
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, α v β 3 and α 5 β 1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely‐related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731–738, 2009