Premium
The cell surface glycoprotein CDCP1 in cancer—Insights, opportunities, and challenges
Author(s) -
Wortmann Andreas,
He Yaowu,
Deryugina Elena I.,
Quigley James P.,
Hooper John D.
Publication year - 2009
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.198
Subject(s) - glycoprotein , cell , cancer , microbiology and biotechnology , cancer research , chemistry , computational biology , biology , biochemistry , genetics
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer. Here we summarize what is known about CDCP1 including its structural features, expression in normal and cancerous tissues, and the in vitro experiments and studies in animal models that have provided the key insights into its potential role in tumor formation and metastasis in humans. We conclude by highlighting opportunities and challenges in targeting CDCP1 in cancer. © 2009 IUBMB IUBMB Life 61(7): 723–730, 2009