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Have we realized the full potential of β‐lactams for treating drug‐resistant TB?
Author(s) -
StoryRoller Elizabeth,
Lamichhane Gyanu
Publication year - 2018
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1875
Subject(s) - antibiotics , medicine , drug , beta lactam , intensive care medicine , drug resistance , broad spectrum , drug class , pharmacology , microbiology and biotechnology , biology , chemistry , combinatorial chemistry
Abstract β‐lactams are the most widely used antibiotics and are effective against a spectrum of pathogenic bacteria. Here, we focus on the state‐of‐the‐art understanding of the molecular underpinnings that determine the overall efficacy of β‐lactams against TB and include historical perspectives of this antibiotic class against this ancient disease. We summarize literature that describes why earlier generations of β‐lactams are ineffective and the potential promise of newer β‐lactams that exhibit improved efficacy against TB. Emerging evidence warrants renewed consideration of newer β‐lactams in regimens for treatment of drug‐resistant TB. © 2018 IUBMB Life, 70(9):881–888, 2018