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Redox‐guided small molecule antimycobacterials
Author(s) -
Kulkarni Amogh,
Sharma Ajay Kumar,
Chakrapani Harinath
Publication year - 2018
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1867
Subject(s) - redox , molecule , chemistry , biophysics , biology , inorganic chemistry , organic chemistry
Abstract The emergence of drug resistance has posed a major challenge to treatment of tuberculosis worldwide. The new drug candidates in the pipeline are few and therefore there is an urgent need to develop antimycobacterials with novel mechanisms of action. Maintenance of redox homeostasis is integral to mycobacterial survival and growth. Therefore, perturbation of this equilibrium can result in irreversible stress induction and inhibition of growth. Herein, we review a number of small molecules that have either been designed to induce redox stress or were found to do so after their discovery. A number of these small molecules are quite effective against drug‐resistant mycobacterial strains and thus offer scope for exploration of potentially new mechanism of action. The progress in redox‐guided antimycobacterial compounds and the challenges towards clinical applications are reviewed. © 2018 IUBMB Life, 70(9):826–835, 2018