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A‐kinase anchoring proteins: From protein complexes to physiology and disease
Author(s) -
Carnegie Graeme K.,
Means Christopher K.,
Scott John D.
Publication year - 2009
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.168
Subject(s) - scaffold protein , signal transduction , phosphorylation , anchoring , protein kinase a , microbiology and biotechnology , signaling proteins , function (biology) , protein function , enzyme , biology , kinase , protein phosphorylation , biochemistry , chemistry , gene , psychology , cognitive science
Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets, but also segregates this activity to prevent indiscriminate phosphorylation of other substrates. One family of diverse, well‐studied scaffolding proteins are the A‐kinase anchoring proteins (AKAPs). These anchoring proteins form multi‐protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function. © 2009 IUBMB IUBMB Life, 61(4): 394–406, 2009