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Research progress of long noncoding RNA in China
Author(s) -
Xing YuHang,
Bai Zhiqiang,
Liu ChuXiao,
Hu ShiBin,
Ruan Meihua,
Chen LingLing
Publication year - 2016
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1564
Subject(s) - biogenesis , biology , rna , computational biology , long non coding rna , genome , non coding rna , noncoding dna , genetics , gene , mechanism (biology) , philosophy , epistemology
RNA is essential for all kingdoms of life and exerts important functions beyond transferring genetic information from DNA to protein. With the advent of the state‐of‐the‐art deep sequencing technology, a large portion of noncoding transcripts in eukaryotic genomes has been broadly identified. Among them, long noncoding RNAs (lncRNAs) have been emerged as a new class of RNA molecules that have regulatory potential in a variety of physiological and pathological processes. Here we summarize recent research progresses that have been made by scientists in China on lncRNAs, including their biogenesis, functional implication and the underlying mechanism of action at the current stage. © 2016 IUBMB Life, 68(11):887–893, 2016