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Molecular basis of antibody‐mediated neutralization and protection against flavivirus
Author(s) -
Dai Lianpan,
Wang Qihui,
Qi Jianxun,
Shi Yi,
Yan Jinghua,
Gao George F.
Publication year - 2016
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1556
Subject(s) - flavivirus , neutralization , virology , antibody , epitope , monoclonal antibody , antibody dependent enhancement , virus , biology , neutralizing antibody , viral envelope , dengue virus , immunology
Antibody‐mediated humoral immunity plays a pivotal role in flavivirus control. Neutralizing antibodies targeting viral envelope (E) protein, provide protection against flaviviruses in vivo but can also promote virus infection by antibody‐dependent enhancement when antibodies are weakly neutralizing or in subneutralizing concentrations. The molecular basis for antibody‐mediated virus neutralization can be revealed by structural studies of monoclonal antibodies complexed with the E protein or virion. In addition, the flavivirus non‐structural protein NS1 can also induce host antibody production, and some of these antibodies can provide protection against virus challenge. In this review, we summarize the known structures of flavivirus neutralizing or protective antibodies bound to their epitopes and describe the underlying molecular mechanisms. © 2016 IUBMB Life, 68(10):783–791, 2016