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Allosteric properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in gas transport and metabolic modulation
Author(s) -
De Rosa Maria Cristina,
Alinovi Cristiana Carelli,
Galtieri Antonio,
Russo Annamaria,
Giardina Bruno
Publication year - 2008
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.15
Subject(s) - hemoglobin , allosteric regulation , chemistry , biophysics , oxygen , oxygen transport , oxidative phosphorylation , molecule , membrane , biochemistry , biology , receptor , organic chemistry
Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo‐ and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand‐linked quaternary transition of hemoglobin in the control of “NO bioactivity” and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule. © 2008 IUBMB IUBMB Life, 60(2): 87–93, 2008