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Umbelliferone attenuates unpredictable chronic mild stress induced‐insulin resistance in rats
Author(s) -
Su Qiang,
Tao Weiwei,
Wang Hanqing,
Chen Yanyan,
Huang Huang,
Chen Gang
Publication year - 2016
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1496
Subject(s) - insulin resistance , insulin , glycogen synthase , medicine , insulin receptor , endocrinology , irs1 , insulin receptor substrate , protein kinase b , tail suspension test , western blot , pi3k/akt/mtor pathway , chemistry , behavioural despair test , phosphorylation , biochemistry , signal transduction , gene , hippocampus , antidepressant
The aim of this study was to investigate whether umbelliferone (Umb) could attenuate insulin resistance in unpredictable chronic mild stress (CUMS)‐induced rats. Behavioral changes were evaluated through sucrose preference test (SPT), open‐field test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)−1, glycogen synthase kinase‐3β, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS‐induced rats. © 2016 IUBMB Life, 68(5):403–409, 2016