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Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts
Author(s) -
Brault Ariane,
Mourer Thierry,
Labbé Simon
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1441
Subject(s) - transcription factor , iron homeostasis , biology , gene , microbiology and biotechnology , psychological repression , repertoire , fission , regulation of gene expression , computational biology , genetics , gene expression , physics , quantum mechanics , acoustics , neutron
When iron load exceeds that needed by fission and filamentous yeasts, iron‐regulatory GATA‐type transcription factors repress genes encoding iron acquisition systems. In contrast, under iron starvation, optimization of cellular iron utilization is coordinated by a specialized regulatory subunit of the CCAAT‐binding factor that fosters repression of genes encoding iron‐using proteins. Despite these findings, there is still limited knowledge concerning the mechanisms by which these iron‐responsive regulators respond to high‐ or low‐iron availability. To provide a framework for understanding common and distinct properties of iron‐dependent transcriptional regulators, a repertoire of their functional domains in different fungal species is presented here. In addition, discovery of interacting partners of these iron‐responsive factors contributes to provide additional insight into their properties. © 2015 IUBMB Life, 67(11):801–815, 2015