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A rescue act: Translesion DNA synthesis past N 2 ‐deoxyguanosine adducts
Author(s) -
Nair Deepak T.,
Kottur Jithesh,
Sharma Rahul
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1403
Subject(s) - deoxyguanosine , dna replication , dna , adduct , dna damage , nucleotide , dna polymerase , biology , polymerase , dna adduct , dna synthesis , 8 hydroxy 2' deoxyguanosine , chemistry , microbiology and biotechnology , biochemistry , genetics , dna oxidation , gene , organic chemistry
Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides—termed as DNA lesions. The N 2 ‐atom of deoxyguanosine is particularly reactive and a number of chemicals react at this site to form different kinds of DNA adducts. The N 2 ‐deoxyguanosine adducts perturb different genomic processes and are particularly deleterious for DNA replication as they have a strong tendency to inhibit replicative DNA polymerases. Many organisms possess specialized dPols—generally classified in the Y‐family—that serves to rescue replication stalled at N 2 ‐dG and other adducts. A review of minor groove N 2 ‐adducts and the known strategies utilized by Y‐family dPols to replicate past these lesions will be presented here. © 2015 IUBMB Life, 67(7):564–574, 2015
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