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MicroRNAs and lncRNAs in senescence: A re‐view
Author(s) -
Bischof Oliver,
MartínezZamudio Ricardo Iván
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1373
Subject(s) - senescence , microrna , biology , chromatin , epigenomics , transcription factor , mechanism (biology) , epigenetics , context (archaeology) , computational biology , phenotype , regulation of gene expression , suppressor , gene , microbiology and biotechnology , non coding rna , gene expression , genetics , dna methylation , paleontology , philosophy , epistemology
Cellular senescence is a stress response to a variety of extrinsic and intrinsic insults that cause genomic or epigenomic perturbations. It is now widely recognized as a potent tumor suppressor mechanism as well as a biological process impacting aging and organismal development. Like other cell fate decisions, senescence is executed and maintained by an intricate network of transcription factors (TFs), chromatin modifiers, and noncoding RNAs (ncRNAs). Altogether, these factors cooperate to implement the gene expression program that initiates and sustains the senescent phenotype. In the context of senescence, microRNAs (miRs) and long ncRNAs have been found to play regulatory roles at both the transcriptional and post‐transcriptional levels. In this review, we discuss recent developments in the field and point toward future research directions to gain a better understanding of ncRNAs in senescence. © 2015 IUBMB Life, 67(4):255–267, 2015