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Modulation of protein synthesis by polyamines
Author(s) -
Igarashi Kazuei,
Kashiwagi Keiko
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1363
Subject(s) - polyamine , spermidine , protein biosynthesis , biochemistry , spermine , microbiology and biotechnology , small molecule , cell growth , escherichia coli , biology , translation (biology) , viability assay , putrescine , chemistry , cell , messenger rna , enzyme , gene
Polyamines are ubiquitous small basic molecules that play important roles in cell growth and viability. Since polyamines mainly exist as a polyamine‐RNA complex, we looked for proteins whose synthesis is preferentially stimulated by polyamines at the level of translation, and thus far identified 17 proteins in Escherichia coli and 6 proteins in eukaryotes. The mechanisms of polyamine stimulation of synthesis of these proteins were investigated. In addition, the role of eIF5A, containing hypusine formed from spermidine, on protein synthesis is described. These results clearly indicate that polyamines and eIF5A contribute to cell growth and viability through modulation of protein synthesis. © 2015 IUBMB Life, 67(3):160–169, 2015