Premium
Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a C hinese population
Author(s) -
Zhang Zhenchang,
Su Gang,
Guo Jia,
Li Jiong,
Wu Hua,
Wang Manxia,
Xie Xiaodong
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1359
Subject(s) - single nucleotide polymorphism , haplotype , genetic predisposition , ischemic stroke , gene , stroke (engine) , genetic association , genetics , methylenetetrahydrofolate reductase , genome wide association study , biology , population , bioinformatics , medicine , genotype , ischemia , mechanical engineering , environmental health , engineering
Up to date, series of studies on ischemic stroke had resulted in inconsistent conclusion. In this study, we aimed to evaluate which specific genes were associated with increased predisposition to stroke in a Chinese population. To identify the specific genes and polymorphisms associated with predisposition to ischemic stroke, we performed high throughput sequenom based next‐generation sequencing from 743 patient with history of ischemic stroke. Variants SNPs in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with IS, thus suggesting involvement of these loci to IS in Chinese patients. Because of different locations on chromosomes, haplotype analyses were not feasible. Our results demonstrate the top level genes that are related to normal vascular physiology, viz. genes of nitric oxide synthesis, endothelial health and smooth muscle biology. Further validation studies are awaited. © 2015 IUBMB Life, 67(3):170–174, 2015