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Ischemia and reperfusion related myocardial inflammation: A network of cells and mediators targeting the cardiomyocyte
Author(s) -
Rohrbach Susanne,
Troidl Christian,
Hamm Christian,
Schulz Rainer
Publication year - 2015
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1352
Subject(s) - ischemia , reperfusion injury , inflammation , cardiac cell , blood flow , medicine , coronary artery occlusion , homeostasis , cardiology , neuroscience , biology
Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network of direct and indirect interactions between cardiomyocytes and resident cell types such as fibroblasts, adipocytes, and endothelial cells or invading blood cells. This review will discuss the role of the cellular interplay in ischemia‐reperfusion injury from a cardiomyocyte‐centered view, although we are aware that other cellular interactions are equally important. We will try to work out currently unresolved questions and potential future directions in the field. © 2015 IUBMB Life, 67(2):110–119, 2015