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Iterative type I polyketide synthases involved in enediyne natural product biosynthesis
Author(s) -
Chen Xiaolei,
Ji Rui,
Jiang Xin,
Yang Rongqiang,
Liu Fuli,
Xin Ying
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1316
Subject(s) - enediyne , thioesterase , biosynthesis , polyketide synthase , natural product , polyketide , chemistry , stereochemistry , biochemistry , computational biology , biology , gene
Enediyne natural products are potent antibiotics structurally characterized by an enediyne core containing two acetylenic groups conjugated to a double bond in a 9‐ or 10‐membered carbocycle. The biosynthetic gene clusters for enediynes encode a novel iterative type I polyketide synthase (PKSE), which is generally believed to initiate the biosynthetic process of enediyne cores. This review article will cover research efforts made since its discovery to elucidate the role of the PKSE in enediyne core biosynthesis. Topics covered include the unique domain architecture, identification, and characterization of turnover products, and interaction with partner thioesterase protein. © 2014 IUBMB Life, 66(9):587–595, 2014