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The strength of aversive and appetitive associations and maladaptive behaviors
Author(s) -
Itzhak Yossef,
PerezLanza Daniel,
Liddie Shervin
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1310
Subject(s) - psychology , reinforcement , classical conditioning , conditioned place preference , addiction , associative learning , aversive stimulus , neuroscience , extinction (optical mineralogy) , fear conditioning , stimulus (psychology) , anxiety , conditioning , cognitive psychology , developmental psychology , amygdala , social psychology , paleontology , statistics , mathematics , psychiatry , biology
Certain maladaptive behaviors are thought to be acquired through classical Pavlovian conditioning. Exaggerated fear response, which can develop through Pavlovian conditioning, is associated with acquired anxiety disorders such as post‐traumatic stress disorders (PTSDs). Inflated reward‐seeking behavior, which develops through Pavlovian conditioning, underlies some types of addictive behavior ( e.g ., addiction to drugs, food, and gambling). These maladaptive behaviors are dependent on associative learning and the development of long‐term memory (LTM). In animal models, an aversive reinforcer (fear conditioning) encodes an aversive contextual and cued LTM. On the other hand, an appetitive reinforcer results in conditioned place preference (CPP) that encodes an appetitive contextual LTM. The literature on weak and strong associative learning pertaining to the development of aversive and appetitive LTM is relatively scarce; thus, this review is particularly focused on the strength of associative learning. The strength of associative learning is dependent on the valence of the reinforcer and the salience of the conditioned stimulus that ultimately sways the strength of the memory trace. Our studies suggest that labile (weak) aversive and appetitive LTM may share similar signaling pathways, whereas stable (strong) aversive and appetitive LTM is mediated through different pathways. In addition, we provide some evidence suggesting that extinction of aversive fear memory and appetitive drug memory is likely to be mediated through different signaling molecules. We put forward the importance of studies aimed to investigate the molecular mechanisms underlying the development of weak and strong memories (aversive and appetitive), which would ultimately help in the development of targeted pharmacotherapies for the management of maladaptive behaviors that arise from classical Pavlovian conditioning. © 2014 IUBMB Life, 66(8):559–571, 2014