Premium
Lumican, a small leucine‐rich proteoglycan
Author(s) -
Nikitovic Dragana,
Katonis Paulos,
Tsatsakis Aristidis,
Karamanos Nikos K.,
Tzanakakis George N.
Publication year - 2008
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.131
Subject(s) - lumican , proteoglycan , microbiology and biotechnology , biology , computational biology , extracellular matrix , decorin
Lumican belongs to the family of small leucine‐rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been correlated to the growth and metastasis of various malignancies; however, its exact role in tumorogenesis remains elusive. This review focuses upon the role of lumican in cell biology, providing insights into molecular mechanisms that lumican likely utilizes to control processes relevant to tumorogenesis. © 2008 IUBMB IUBMB Life, 60(12): 818–823, 2008