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NAC transcription factor gene regulatory and protein–protein interaction networks in plant stress responses and senescence
Author(s) -
Jensen Michael K.,
Skriver Karen
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1256
Subject(s) - transcription factor , gene , biology , computational biology , protein–protein interaction , transcription (linguistics) , gene regulatory network , senescence , genetics , microbiology and biotechnology , gene expression , philosophy , linguistics
Plant‐specific NAM/ATAF/CUC (NAC) transcription factors (TFs) have recently received considerable attention due to their significant roles in plant development and stress signaling. Here, we summarize progress in understanding NAC TFs in stress responses and senescence. We focus on interactions between the DNA‐binding NAC domain and target genes, and between the large, mostly disordered transcription regulatory domain of NAC TFs and protein interaction partners. Recent studies have identified both up‐stream regulators of NAC genes and down‐stream NAC target genes, outlining regulatory networks associated with NAC–protein interactions. This connects molecular interactions and signal pathway intersections with biological functions with promising use in agriculture. © 2014 IUBMB Life, 66(3):156–166, 2014