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The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism
Author(s) -
Fiorino Erika,
Giudici Marco,
Ferrari Alessandra,
Mitro Nico,
Caruso Donatella,
De Fabiani Emma,
Crestani Maurizio
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1246
Subject(s) - sirtuin , epigenetics , biology , histone deacetylase , histone , computational biology , lipid metabolism , sirt6 , disease , gene , bioinformatics , genetics , acetylation , medicine , biochemistry , pathology
After the completion of the human genome sequence and that from many other organisms, last decade has witnessed a spectacular gain of knowledge on gene functions. These studies provided new insights on the roles of genes in physiology and disease. Nonetheless, the availability of genetically modified models and of “omics” technologies such as next generation sequencing unveiled clear evidences on epigenetic regulation of many cellular functions. At this regard, sirtuins, belonging to class III histone deacetylase family, have emerged as regulators of metabolism as well as other cellular processes and seem ideally suited as targets of future therapeutical interventions. This review deals on general aspects of the biology of sirtuins and focuses on their relevance in lipid metabolism in different tissues, pointing to their exploitation as potential pharmacological targets of compounds that could be used as new therapeutic alternatives in several disorders ranging from type 2 diabetes and obesity to age‐related cardiovascular and neurodegenerative diseases. © 2014 IUBMB Life, 66(2):89–99, 2014