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Processing, signaling, and physiological function of chemerin
Author(s) -
Mattern Andreas,
Zellmann Tristan,
BeckSickinger Annette G.
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1242
Subject(s) - chemerin , chemokine , chemotaxis , inflammation , proteases , receptor , microbiology and biotechnology , adipose tissue , biology , chemokine receptor , function (biology) , ccr1 , immunology , endocrinology , adipokine , biochemistry , insulin resistance , insulin , enzyme
Chemerin is an immunomodulating factor secreted predominantly by adipose tissue and skin. Processed by a variety of proteases linked to inflammation, it activates the G‐protein coupled receptor chemokine‐like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells. Recent developments revealed the role of the nonsignaling chemerin receptor C‐C chemokine receptor‐like 2 (CCRL2) in inflammation. Besides further research establishing its link to inflammatory skin conditions such as psoriasis, functions in healthy skin have also been reported. Here, the current understanding of chemerin processing, signaling and physiological function has been summarized, focusing on the regulation of its activity, its different receptors and its controversially discussed role in diseases. © 2014 IUBMB Life, 66(1):19–26, 2014