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SUMO Ubc9 enzyme as a viral target
Author(s) -
Varadaraj Archana,
Mattoscio Domenico,
Chiocca Susanna
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1240
Subject(s) - sumo protein , effector , microbiology and biotechnology , enzyme , infectivity , biology , repertoire , sumo enzymes , viral protein , chemistry , biochemistry , virology , virus , ubiquitin , physics , gene , acoustics
Viruses alter specific host cell targets to counteract possible defense mechanisms aimed at eliminating infectivity and viral propagation. The SUMO conjugating enzyme Ubc9 functions as a hub for protein sumoylation, whilst also providing an interactive surface for sumoylated proteins through noncovalent interactions. The targeting of Ubc9 by viruses and viral proteins is thus highly beneficial for the disruption of both protein modification and protein‐protein interaction mechanisms with which proteins increase their functional repertoire in cells. This review explores some of the clever mechanisms adopted by viruses to deregulate Ubc9, influence effector pathways and positively impact viral persistence consequently. © 2014 IUBMB Life, 66(1):27–33, 2014