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Genomic lens on neuroglobin transcription
Author(s) -
Cutrupi Santina,
Ferrero Giulio,
Reineri Stefania,
Cordero Francesca,
De Bortoli Michele
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1235
Subject(s) - neuroglobin , biology , neuroprotection , transcription factor , zebrafish , transcription (linguistics) , epigenetics , gene , enhancer , genetics , globin , microbiology and biotechnology , neuroscience , linguistics , philosophy
Abstract Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O 2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease. © 2014 IUBMB Life, 66(1):46–51, 2014.