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Nitric oxide, S ‐Nitrosation, and endothelial permeability
Author(s) -
Durán Walter N.,
Beuve Annie V.,
Sánchez Fabiola A.
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1204
Subject(s) - enos , nitrosation , nitric oxide , adherens junction , endothelial nitric oxide synthase , chemistry , microbiology and biotechnology , cytosol , nitric oxide synthase type iii , nitric oxide synthase , biochemistry , biophysics , biology , enzyme , cadherin , organic chemistry , cell
S ‐Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro‐inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)‐derived nitric oxide (NO) in regulating S ‐Nitrosation of adherens junction proteins. We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S ‐Nitrosation and onset of endothelial hyperpermeability to macromolecules. © 2013 IUBMB Life, 65(10):819‐826, 2013