Homer Proteins in Ca 2+  Entry | Zendy

Jardin Isaac | Zendy; López José J. | Zendy; BernaErro Alejandro | Zendy; Salido Ginés M. | Zendy; Rosado Juan A. | Zendy

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Homer Proteins in Ca 2+ Entry

Author(s) -

Jardin Isaac,

López José J.,

BernaErro Alejandro,

Salido Ginés M.,

Rosado Juan A.

Publication year - 2013

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1002/iub.1162

Subject(s) - leucine zipper , signal transducing adaptor protein , endoplasmic reticulum , microbiology and biotechnology , metabotropic receptor , metabotropic glutamate receptor , ionotropic effect , chemistry , scaffold protein , biochemistry , biology , receptor , glutamate receptor , signal transduction , peptide sequence , gene

The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms. Homer1 family presents an EVH1 domain, a coiled coil domain and two leucine zipper domains. Homer proteins regulate a number of Ca2+‐handling proteins, including transient receptor potential channels and other Ca2+‐permeable channels, ionotropic and metabotropic glutamate receptors, shank scaffolding proteins or endoplasmic reticulum Ca2+ release channels. This review article focuses on the association of Homer 1 proteins with Ca2+‐handling proteins and their role on intracellular Ca2+‐homeostasis. © 2013 IUBMB Life, 65(6):–, 2013

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