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Mechanisms of mitochondrial translational regulation
Author(s) -
Fontanesi Flavia
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1156
Subject(s) - mitochondrion , mitochondrial ribosome , microbiology and biotechnology , cytochrome c oxidase , biology , biogenesis , biochemistry , saccharomyces cerevisiae , mitochondrial biogenesis , oxidative phosphorylation , inner mitochondrial membrane , atp synthase , post translational regulation , yeast , phosphorylation , enzyme , ribosome , gene , rna
The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc 1 complex, cytochrome c oxidase and the F 1 F O ATP synthase contain subunits of dual genetic origin. It has been recently established that key subunits of these enzymes, translated on mitochondrial ribosomes, are the subjects of assembly‐dependent translational regulation. This type of control of gene expression plays a pivotal role in optimizing the biogenesis of mitochondrial respiratory membranes by coordinating protein synthesis and complex assembly and by limiting the accumulation of potentially harmful assembly intermediates. Here, the author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field. © 2013 IUBMB Life, 65(5): 397–408, 2013