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The diversity‐oriented synthesis of pteridines—achievements and potential for development
Author(s) -
Suckling Colin J.
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1148
Subject(s) - cofactor , chemistry , pteridine , combinatorial chemistry , electrophile , computational biology , biology , biochemistry , catalysis , enzyme
The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or biological probes. Recently, diversity‐oriented synthesis has become a particularly powerful and versatile approach to the synthesis of pteridines and related heterocyclic compounds. This article describes and discusses available methods using radical, electrophilic, nucleophilic, and organometal mediated substitution reactions. © 2013 IUBMB Life 65(4):283–299, 2013.