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The proteasome and its role in the degradation of oxidized proteins
Author(s) -
Jung Tobias,
Grune Tilman
Publication year - 2008
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.114
Subject(s) - proteasome , microbiology and biotechnology , oxidative phosphorylation , chemistry , protein degradation , proteolysis , degradation (telecommunications) , biochemistry , biology , enzyme , telecommunications , computer science
Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed in order to prevent serious metabolic disturbances. The most important cellular proteolytic system responsible for the removal of oxidized proteins is the proteasomal system. For normal functioning, the proteasomal system needs the coordinated interaction of numerous components. This review describes the fundamental functions of the 20S “core” proteasome, its regulators, and the roles of the proteasomal system beyond the removal of oxidized proteins in mammalian cells. © 2008 IUBMB IUBMB Life, 60(11): 743–752, 2008