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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease
Author(s) -
Cui Hao,
Freeman Craig,
Jacobson Glenn A.,
Small David H.
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1118
Subject(s) - central nervous system , pathogenesis , extracellular matrix , neuroscience , disease , nervous system , neural development , biology , alzheimer's disease , proteoglycan , microbiology and biotechnology , medicine , biochemistry , immunology , gene , pathology
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD. © 2013 IUBMB Life, 65(2)108–120, 2013.