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Physiological functions of protein kinase D in vivo
Author(s) -
Ellwanger Kornelia,
Hausser Angelika
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1116
Subject(s) - microbiology and biotechnology , kinase , protein kinase a , biology , golgi apparatus , in vivo , gene , threonine , protein kinase c , serine , phosphorylation , genetics , endoplasmic reticulum
The cellular functions of the serine/threonine protein kinase D (PKD) have been extensively studied within the last decade and distinct roles such as fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription have been correlated with this kinase family. Here, we highlight the current state of in vivo studies on PKD function with a focus on animal models and discuss the molecular basis of the observed phenotypic characteristics associated with this kinase family. © 2013 IUBMB Life, 65(2)98–107, 2013