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Amyloid beta accumulation in HIV‐1‐infected brain: The role of the blood brain barrier
Author(s) -
András Ibolya E.,
Toborek Michal
Publication year - 2013
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1106
Subject(s) - blood–brain barrier , amyloid (mycology) , human immunodeficiency virus (hiv) , beta (programming language) , amyloid beta , medicine , virology , pathology , immunology , chemistry , central nervous system , disease , computer science , programming language
In recent years, we face an increase in the aging of the HIV‐1‐infected population, which is not only due to effective antiretroviral therapy but also to new infections among older people. Even with the use of the antiretroviral therapy, HIV‐associated neurocognitive disorders represent an increasing problem as the HIV‐1‐infected population ages. Increased amyloid beta (Aβ) deposition is characteristic of HIV‐1‐infected brains, and it has been hypothesized that brain vascular dysfunction contributes to this phenomenon, with a critical role suggested for the blood‐brain barrier in brain Aβ homeostasis. This review will describe the mechanisms by which the blood‐brain barrier may contribute to brain Aβ accumulation, and our findings in the context of HIV‐1 infection will be discussed. © 2012 IUBMB Life, 65(1):43–49, 2013