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Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models
Author(s) -
Møller Peter,
Risom Lotte,
Lundby Carsten,
Mikkelsen Lone,
Loft Steffen
Publication year - 2008
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.109
Subject(s) - lipid peroxidation , hypoxia (environmental) , dna damage , oxidative stress , dna oxidation , medicine , exertion , chemistry , dna , physiology , biochemistry , endocrinology , biology , toxicology , oxygen , organic chemistry
The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose‐response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity. © 2008 IUBMB IUBMB Life, 60(11): 707–723, 2008