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Enemy or partner: Relationship between intronic micrornas and their host genes
Author(s) -
Gao Xu,
Qiao Yu,
Han Dong,
Zhang Yanfen,
Ma Ning
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1079
Subject(s) - microrna , gene , biology , genetics , intron , function (biology) , gene expression , computational biology , regulation of gene expression
In the past several years, microRNAs have been identified as a class of important regulators of gene expression. One hot topic in the microRNA field is the location of microRNA genes. Most microRNAs are called intronic microRNAs, which are encoded in the introns of coding or non‐coding genes. Some research studies have shown that intronic miRNAs coexpress and act similarly to their host genes; however, other research studies have suggested that their level of expression and function are opposite to that of their host genes. Intronic microRNAs have been reported to play an antagonistic or synergetic role as an enemy or a partner of their host genes. Elucidation of the relationship between intronic microRNAs and their host genes will facilitate a deeper understanding of gene expression and the function of introns. This mini review will discuss recent research addressing intronic microRNAs and their host genes. © 2012 IUBMB IUBMB Life, 64(10): 835–840, 2012