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TAK1, more than just innate immunity
Author(s) -
Dai Liang,
Aye Thu Chan,
Liu XinYu,
Xi Jiajia,
Cheung Peter C. F.
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1078
Subject(s) - microbiology and biotechnology , innate immune system , proinflammatory cytokine , wnt signaling pathway , signal transduction , biology , regulator , immunology , immune system , inflammation , biochemistry , gene
Transforming growth factor β‐activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor necrosis factor‐α, and toll‐like receptor agonists, it mediates the activation of the nuclear factor κB (NF‐κB), c‐Jun N‐terminal kinase (JNK), and p38 pathways. In addition, TAK1 plays a central role in adaptive immunity, in which it mediates signaling from T‐ and B‐cell receptors. This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor‐β, Wnt, osmotic stress, and hypoxia. © 2012 IUBMB IUBMB Life, 2012, 64(10):825–834, 2012