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The biological regulation of ABCE1
Author(s) -
Tian Ye,
Han Xu,
Tian Dali
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1071
Subject(s) - rnase p , capsid , biology , microbiology and biotechnology , translation (biology) , virus , gene , chemistry , virology , messenger rna , rna , biochemistry
ATP binding cassette E1 (ABCE1) protein, also named RLI or HP68, is one member of ATP binding cassette superfamily. By forming a heterodimer with RNase L, ABCE1 protein inhibits the IFN‐depended 2‐5A/RNase L system and regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis. As a highly conserved protein, recent studies have mainly focused that ABCE1 protein is involving in the fields of HIV virus capsids assembly and important roles in translation. Our manuscript will review the studies which revealed the biological regulation of ABCE1. © 2012 IUBMB IUBMB Life, 64(10): 795–800, 2012