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Autophagy as a macrophage response to bacterial infection
Author(s) -
Gong Lan,
Devenish Rodney J.,
Prescott Mark
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1070
Subject(s) - autophagy , phagocytosis , macrophage , secretion , proinflammatory cytokine , intracellular parasite , bacteria , immune system , microbiology and biotechnology , intracellular , biology , inflammation , immunology , biochemistry , apoptosis , in vitro , genetics
The macrophage is a key component of host defense mechanisms against pathogens. In addition to the phagocytosis of bacteria and secretion of proinflammatory mediators by macrophages, autophagy, a process involved in turnover of cellular material, is a recently identified component of the immune response to bacterial infection. Despite the bactericidal effect of autophagy, some species of intracellular bacteria are able to survive by using one or more strategies to avoid host autophagic attack. Here, we review the latest findings on the interactions between bacteria and autophagy in macrophages. © 2012 IUBMB Life, 64(9): 740–747, 2012