Premium
Recent progress in NMR spectroscopy: Toward the study of intrinsically disordered proteins of increasing size and complexity
Author(s) -
Felli Isabella C.,
Pierattelli Roberta
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1045
Subject(s) - intrinsically disordered proteins , nuclear magnetic resonance spectroscopy , nanotechnology , function (biology) , chemistry , materials science , biology , biochemistry , microbiology and biotechnology , organic chemistry
Thanks to recent fast progress, NMR is now in a strategic position to provide unique atomic resolution information on a variety of different biological macromolecules in different conditions (solution, solid state, in‐cell). We would like here to present recent developments that enable to focus on intrinsically disordered proteins (IDPs) or intrinsically disordered regions (IDRs) of proteins of increasing size and complexity. They have attracted the attention of the scientific community challenging well accepted ideas and concepts and demanding an expansion of the structure function paradigm. © 2012 IUBMB IUBMB Life, 2012.