Premium
The role of PGC‐1 coactivators in aging skeletal muscle and heart
Author(s) -
Dillon Lloye M.,
Rebelo Adriana P.,
Moraes Carlos T.
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1010
Subject(s) - mitochondrial biogenesis , skeletal muscle , biogenesis , mitochondrion , biology , function (biology) , organelle biogenesis , microbiology and biotechnology , endocrinology , medicine , bioinformatics , genetics , gene
Abstract Aging is the progressive decline in cellular, tissue, and organ function. This complex process often manifests as loss of muscular strength, cardiovascular function, and cognitive ability. Mitochondrial dysfunction and decreased mitochondrial biogenesis are believed to participate in metabolic abnormalities and loss of organ function, which will eventually contribute to aging and decreased lifespan. In this review, we discuss what is currently known about mitochondrial dysfunction in the aging skeletal muscle and heart. We focused our discussion on the role of PGC‐1 coactivators in the regulation of mitochondrial biogenesis and function and possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and circumventing aging and aging‐related diseases. © 2012 IUBMB IUBMB Life, 2012